We often end up adjusting our schedules and sleep routine to keep pace with the daily hustle bustle of life. To meet with the workload, we may go the extra mile and subtract a couple of hours from our sleep schedule.
Apparently, this may culminate in a few yawns and a drowsy next day. However, that’s not all. The increased exposure to artificial light such as blue light from your smartphone disturbs your sleep clock. When we mess up with circadian rhythm or the internal body clock that regulates sleep, we disturb the body clocks that regulate the automated processes that take place in the body.
The body clocks control your metabolism that, in turn, chips in the proper functioning of all the organs in the body. However, working through the night, spending long hours, looking at bright screens, and traveling long-distance can negatively affect the body clock, leaving it disoriented.
Let’s walk you through more on this according to what the latest research has found.
The Latest Study on the Health Consequences of Disturbed Body Clocks
The latest research is seen in the publication PNAS. It has been conducted by the University of Southern California in Los Angeles, the Nagoya University in Japan, and The Scripps Research Institute in La Jolla, CA.
Researchers unearthed the mechanism that associated the disturbance of circadian rhythm with an increased risk of chronic diseases. The study author notes that there is mounting evidence that suggests that the modern lifestyle clashes with the internal biological clock. Unfortunately, this clash leads to the development of diseases such as breast cancer and obesity.
This study dives deeper into the matter to explore the dysregulated circadian rhythm as a risk factor for some diseases.
The Focus and Finding of the Study
The researchers of this study paid attention to a protein titled HNF4A in the cell nuclei. Early research has revealed that this protein is involved in the early development of the kidney, liver, and large intestine.
When the researchers analyzed the colon and liver cells from human and mouse tissue, they learned that HNF4A interact with the internal biological clock of these cells. The protein can block two other proteins titled BMAL1 and CLOCK. These assist in regulating the circadian rhythm in mammals.
Furthermore, the scientists outlined that HNF4A responds to the chemical signals in the cells and act on other proteins as per the signals received. In simple words, when HNFFA’s activity is disturbed, the normal metabolism process also gets disturbed. This exposes other organs to diseases.
The mechanism explains how a haywire sleep cycle can affect your health. The study author, Steve Kay, put this as, “So, in the liver, we looked at tissue-specific proteins and found that HNF4A is tied to the circadian clock, is regulated by the clock and cycles with the clock and, in turn, regulates the clock. That’s the new finding here, and it’s a big jump forward.”
This study proves that modern lifestyle can reach a finale of poor health. Therefore, it is best to try and maintain a sleep schedule to promote health wellbeing in the long haul.